ea0081rc6.2 | Rapid Communications 6: Endocrine-Related Cancer | ECE2022
Cuny Thomas
, Mondielli Gregoire
, van Koetsveld Peter
, de Herder Wouter
, Barlier Anne
, Hofland Leo
Introduction: Pancreatic neuroendocrine neoplasms (PNEN) present with a fibrotic stroma which constitutes the tumor microenvironment (TME). The role played by stromal fibroblasts over the growth of PNEN and their sensitivity to the mTOR inhibitor, RAD001, are as yet unestablished.Methods: We investigated reciprocal interactions between 1) human PNEN cell lines (BON-1/QGP-1) or primary cultures of human ileal neuroendocrine neoplasm (iNEN) or PNEN, and 2)...